AI SearchChemopreventive properties of stilbene derivatives in human breast and prostate cancer cell lines (Record no. 16796)
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| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20260817172620.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 100204s2009 th uu|m rtt 0| a1eng d |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | .b12072643 |
| 099 #9 - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | AIT Diss. no.EV-09-05 |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sunisa Sangjun |
| 245 10 - TITLE STATEMENT | |
| Title | Chemopreventive properties of stilbene derivatives in human breast and prostate cancer cell lines |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Pathum Thani, Thailand : |
| Name of publisher, distributor, etc. | Asian Institute of Technology, |
| Date of publication, distribution, etc. | 2009 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 1 online resource (97 p.) : |
| Other physical details | ill. |
| 490 1# - SERIES STATEMENT | |
| Series statement | Dissertation ; |
| Volume/sequential designation | no. EV-09-05 |
| 500 ## - GENERAL NOTE | |
| General note | A dissertation submitted in partial fulfillment of the requirements for thedegree of Doctor of Technical Science in Environmental Engineering and ManagementInter-University Program on Environmental Toxicology, Technology and Management |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Asian Institute of Technology - Chulabhorn Research Institute - Mahidol University, 2009 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Thirteen cis-stilbene derivatives (CRI-1 - CRI-13) related to VIOXX®were synthesized and studied for their chemopreventive properties in human breast cancer and prostate cancer cell lines. Based on the different substituents in the stilbene molecule, we established a structure activity relationship (SAR) for cytotoxicity, anti-estrogenicity, cell cycle analysis and apoptosis. The results show that some of these stilbenes have a pronounced effect on these chemopreventive properties. In MCF -7 breast cancer cells, CRI-5, 7, 10, and CRI-12 caused an arrest of the G2/M phase and a reduction of G 1/S phase at various dose levels. CRI -9 only arrest the G 1/S phase in a dose-dependent manner. In addition, some CRr congeners, CRI-6 and 9, have a moderate anti-estrogenic effect. In the LNCaP, prostate cancer cells CRI-5, 7, and 12 arrest the cell cycle in G2/M phase and induced apoptosis. A first SAR for these cis-stilbene derivatives was identified. The presence and position of methoxy and thiomethoxy groups are essential for the tested chemopreventive properties and substitution on the para position of these substituents on the left aromatic ring is a prerequisite. The study shows that some of these synthetic cis-stilbene derivatives have the potential to be chemopreventive agents, as these can effectively interfere with cellular processes those are important for anti-cancer treatment. As these experiments have all been done in tumor cell lines further studies are necessary to identify if these anti-tumor properties can also be found in in vivo situations |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Stilbene |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cancer cells |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cancer |
| General subdivision | Chemoprevention |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Somsak Ruchirawat, |
| Relator term | Chairperson |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Van Den Berg, Martin, |
| Relator term | Co-Chairperson |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chongrak Polprasert, |
| Relator term | Examination Committee |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Preeda Pakpian, |
| Relator term | Examination Committee |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | Chulabhorn Research Institute, |
| Relator term | Scholarship donor |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | Mahidol University, |
| Relator term | Scholarship donor |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | Asian Institute of Technology Fellowship, |
| Relator term | Scholarship donor |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | Institute for Risk Assessment Sciences (IRAS), Utrecht University, The Netherlands, |
| Relator term | Scholarship Donor |
| 810 2# - SERIES ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | Asian Institute of Technology. |
| Title of a work | Dissertation ; |
| Volume/sequential designation | no. EV-09-05 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Materials specified | Full-Text |
| Uniform Resource Identifier | <a href="http://203.159.5.9/ait-thesis/detail.php?q=B00552">http://203.159.5.9/ait-thesis/detail.php?q=B00552</a> |
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| Cataloger's initials, CIN (RLIN) | 100204 |
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| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | 20-AIT Publication |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | 40-Archives |
| 909 ## - LOCAL ITEMS USED | |
| Barcode | Barcode : 30050120553960 |
| CREATED | CREATED : 2010-04-02 |
| RECORD Id | RECORD # : i12628074 |
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| CREATED | CREATED : 2016-09-02 |
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| Withdrawn status | Lost status | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Cost, normal purchase price | Total checkouts | Full call number | Barcode | Date last seen | Copy number | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Available for Loans | Asian Institute of Technology Library | Asian Institute of Technology Library | AIT Publications | 17/08/2026 | 50.00 | AIT Diss. no.EV-09-05 | 30050120553960 | 17/08/2026 | 1 | 17/08/2026 | 20-AIT Publication | ||||
| Available for Loans | Asian Institute of Technology Library | Asian Institute of Technology Library | Archives | 17/08/2026 | AIT Diss. no.EV-09-05 | 30050160004171 | 17/08/2026 | 17/08/2026 | 40-Archives |