AI SearchChitosan microspheres and beads for the sustained release of theophylline (Record no. 17093)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03160nas|a2200397 i 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20260817172702.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 200717s2001 th u m rtt 00| a1eng d |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | .b11861381 |
| 099 #9 - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | AIT Thesis no. BP-01-01 |
| 100 1# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Cruz, Pedro Miguel Filipe |
| 245 10 - TITLE STATEMENT | |
| Title | Chitosan microspheres and beads for the sustained release of theophylline |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Bangkok : |
| Name of publisher, distributor, etc. | Asian Institute of Technology, |
| Date of publication, distribution, etc. | 2001 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 66 leaves |
| 490 1# - SERIES STATEMENT | |
| Series statement | Thesis ; |
| Volume/sequential designation | no. BP-01-01 |
| 500 ## - GENERAL NOTE | |
| General note | A thesis submitted in pa1iial fulfillment of the requirements for the degree of Master of Science, School of Environment, Resources and Development |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Asian Institute of Technology, 2001 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The main purpose of this study was to develop a sustained delivery system based on the0phylline containing chitosan microspheres obtained by an optimized spray drying technique. Theophylline is an extensively used bronchodilator with a half-life of 5 hours. Due to its narrow therapeutic levels, it should be applied preferentially in a well-controlled delivery system. The spray drier LabPlant SD-05 was used to microencapsulate the theophylline into a chitosan microspheres. Several operational parameters and theophylline: chitosan ratios were investigated in order to establish a correlation with the dissolution characteristics and loading efficiency. Spherical chitosan microspheres loaded with theophylline were about 5 æm in diameter. It was found that a lower chitosan concentration (0.5% w/v) and theophylline: chitosan ratio (20% w/w) resulted in the best loading efficiency and sustained release. This suggests a more effective heat and mass transfer and therefore better drying conditions for proper entrapment of the drug. Additionally chitosan beads loaded with theophylline were prepared by ionotropic gelation technique: dropping chitosan/theophylline solution into a coagulation bath of penta-sodium tripolyphosphate (TPP). A very low total release, dependent on the theophylline content, was attained, likely due to the agglomeration of the beads under the conditions used. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Chitosan |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Theophylline |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Suwalee Chandrkrachang, |
| Relator term | Chairperson |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Preeda Pakpian, |
| Relator term | Examination Committee |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Suwabun Chirachanchai, |
| Relator term | Examination committee |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | Post graduated Studies Program (PTS) European Commission, |
| Relator term | Scholarship donor |
| 810 2# - SERIES ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | Asian Institute of Technology. |
| Title of a work | Thesis ; |
| Volume/sequential designation | no. BP-01-01 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Materials specified | Full-Text |
| Uniform Resource Identifier | <a href="http://203.159.5.9/ait-thesis/detail.php?q=B07818">http://203.159.5.9/ait-thesis/detail.php?q=B07818</a> |
| 907 ## - LOCAL DATA ELEMENT G, LDG (RLIN) | |
| a | .b11861381 |
| b | mnait |
| c | u |
| 902 ## - LOCAL DATA ELEMENT B, LDB (RLIN) | |
| a | 240402 |
| 998 ## - LOCAL CONTROL INFORMATION (RLIN) | |
| Operator's initials, OID (RLIN) | 0 |
| Cataloger's initials, CIN (RLIN) | 020717 |
| First date, FD (RLIN) | m |
| -- | a |
| -- | u |
| -- | 0 |
| 945 ## - LOCAL PROCESSING INFORMATION (OCLC) | |
| l | mnait |
| 945 ## - LOCAL PROCESSING INFORMATION (OCLC) | |
| l | mnarc |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | 22-AIT Thesis (Replacement) |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | 40-Archives |
| 909 ## - LOCAL ITEMS USED | |
| Barcode | Barcode : 30050120683130 |
| CREATED | CREATED : 2013-06-09 |
| RECORD Id | RECORD # : i12740032 |
| LPATRON | LPATRON : 1024926 |
| LCHKIN | LCHKIN : 2014-01-23 |
| RENEWALS | # RENEWALS : 0 |
| -- | # OVERDUE : 0 |
| -- | IUSE3 : 0 |
| -- | TOT CHKOUT : 1 |
| -- | TOT RENEW : 1 |
| 909 ## - LOCAL ITEMS USED | |
| Barcode | Barcode : 30050120350854 |
| CREATED | CREATED : 2016-10-06 |
| RECORD Id | RECORD # : i13029666 |
| LPATRON | LPATRON : 0 |
| LCHKIN | LCHKIN : - |
| RENEWALS | # RENEWALS : 0 |
| -- | # OVERDUE : 0 |
| -- | IUSE3 : 0 |
| -- | TOT CHKOUT : 0 |
| -- | TOT RENEW : 0 |
| Withdrawn status | Lost status | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Cost, normal purchase price | Total checkouts | Full call number | Barcode | Date last seen | Copy number | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Available for Loans | Asian Institute of Technology Library | Asian Institute of Technology Library | AIT Publications | 17/08/2026 | 50.00 | AIT Thesis no. BP-01-01 | 30050120683130 | 17/08/2026 | 3 | 17/08/2026 | 22-AIT Thesis (Replacement) | ||||
| Available for Loans | Asian Institute of Technology Library | Asian Institute of Technology Library | Archives | 17/08/2026 | AIT Thesis no. BP-01-01 | 30050120350854 | 17/08/2026 | 17/08/2026 | 40-Archives |