AI SearchEffects of arsenic exposure on inflammatory responses in human lymphoblast cell line and arsenic exposed children (Record no. 35014)
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| fixed length control field | 04876nam a2200469 a 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20260818095214.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 140612s2013 th ad ||| |000 0 eng d |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | .b12131246 |
| 099 #9 - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | AIT Thesis no.EV-13-12 |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Moh Moh Thant Zin |
| 245 10 - TITLE STATEMENT | |
| Title | Effects of arsenic exposure on inflammatory responses in human lymphoblast cell line and arsenic exposed children |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Pathum Thani : |
| Name of publisher, distributor, etc. | Asian Institute of Technology, |
| Date of publication, distribution, etc. | 2013 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 57 leaves : |
| Other physical details | maps, charts + |
| Accompanying material | 1 online resource |
| 490 1# - SERIES STATEMENT | |
| Series statement | Thesis ; |
| Volume/sequential designation | no. EV-13-12 |
| 500 ## - GENERAL NOTE | |
| General note | A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Environmental Engineering and Management Inter-University Program on Environmental Toxicology, Technology and Management |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Asian Institute of Technology - Chulabhorn Research Institute - Mahidol University, 2013 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Arsenic, a ubiquitous environmental pollutant, is a known human carcinogen. Exposure to arsenic has been associated with cancer and chronic diseases in human such as diabetes mellitus and ischemic heart diseases as a result of arsenic induced inflammation. A number of studies reported that prenatal arsenic exposure has been related to health risk of children. This study aimed to assess arsenic exposure and inflammatory responses in vitro and in arsenic-exposed-children. Arsenic-exposed-children from Ron Pibul sub-district and matched control children were recruited in this study. Arsenic exposure was determined by measurement of arsenic contamination in water (household drinking and non-drinking water), arsenic contamination in saliva (biomarker of arsenic exposure) as well as evaluates level of pro-inflammatory cytokines, IL-6 and IL-8, as a biomarker of inflammatory responses. In vitro determination of pro-inflammatory cytokines was performed using lymphoblast cell line. The study clearly demonstrated a dose-response relationship between level of arsenic treatment and pro-inflammatory gene expression in lymphoblast cell line which statistically significant was observed at 10oM. For human study, the level of arsenic in drinking water and non-drinking water consumed by arsenic-exposed-children were statistically significantly higher than control children by 2-fold (P< 0.01) and 10-fold, (P< 0.001) respectively. Salivary arsenic concentration in exposed-children was also statistically significantly higher than control children by 5-fold (P<0.05). The pro-inflammatory gene expression determined in saliva showed that IL-6 in exposed-children was 1.5-fold higher than the control children, while IL-8 gene expression was 1.8-fold statistically significantly (P<0.05) higher than the exposed-children. Although arsenic concentration in water was higher in exposed site, the mean arsenic level in the drinking water was in the acceptable range of WHO guideline (10 og/L). The significant correlation between IL-6 and total arsenic concentration in children{u2019}s saliva suggested that arsenic-exposed-children may increase in risk of inflammatory diseases later in life. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Water |
| General subdivision | Purification |
| -- | Arsenic removal |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Arsenic waste |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Lymphoblastoid cell lines |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Panida Navasumrit, |
| Relator term | Chairperson |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Shipin, Oleg V., |
| Relator term | Examination Committee |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jantamas Kanitwithayanun, |
| Relator term | Examination committee |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Pornpat Intarasunanont, |
| Relator term | Examination committee |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | Deutscher Akademischer Austausch Dienst (DAAD), Germany, |
| Relator term | Scholarship donor |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | Asian Institute of Technology Fellowship, |
| Relator term | Scholarship donor |
| 810 2# - SERIES ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | Asian Institute of Technology. |
| Title of a work | Thesis ; |
| Volume/sequential designation | no. EV-13-12 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Materials specified | Full-Text |
| Uniform Resource Identifier | <a href="http://203.159.5.9/ait-thesis/detail.php?q=B02548">http://203.159.5.9/ait-thesis/detail.php?q=B02548</a> |
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| 998 ## - LOCAL CONTROL INFORMATION (RLIN) | |
| Operator's initials, OID (RLIN) | 0 |
| Cataloger's initials, CIN (RLIN) | 140612 |
| First date, FD (RLIN) | m |
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| 962 ## - | |
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| -- | Abstract -- AIT Thesis no. EV-13-12 |
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| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | 20-AIT Publication |
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| Koha item type | 40-Archives |
| 909 ## - LOCAL ITEMS USED | |
| Barcode | Barcode : 30050120735310 |
| CREATED | CREATED : 2014-12-06 |
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| Withdrawn status | Lost status | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Cost, normal purchase price | Total checkouts | Full call number | Barcode | Date last seen | Copy number | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Available for Loans | Asian Institute of Technology Library | Asian Institute of Technology Library | AIT Publications | 18/08/2026 | 50.00 | AIT Thesis no.EV-13-12 | 30050120735310 | 18/08/2026 | 1 | 18/08/2026 | 20-AIT Publication | ||||
| Available for Loans | Asian Institute of Technology Library | Asian Institute of Technology Library | AIT Publications | 18/08/2026 | 50.00 | AIT Thesis no.EV-13-12 | 30050120735286 | 18/08/2026 | 2 | 18/08/2026 | 20-AIT Publication | ||||
| Available for Loans | Asian Institute of Technology Library | Asian Institute of Technology Library | Archives | 18/08/2026 | AIT Thesis no.EV-13-12 | 30050160047667 | 18/08/2026 | 18/08/2026 | 40-Archives |