AI SearchEffects of pesticides on the non-neuronal lymphocytic cholinergic system (Record no. 35276)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 04683nas a2200457 a 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20260818095308.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 110606s2010 th uu|m rtt 0| a1eng d |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | .b12096404 |
| 099 #9 - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | AIT Diss. no.EV-10-06 |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Tanvisith Charoenying |
| 245 10 - TITLE STATEMENT | |
| Title | Effects of pesticides on the non-neuronal lymphocytic cholinergic system |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Pathum Thani, Thailand : |
| Name of publisher, distributor, etc. | Asian Institute of Technology, |
| Date of publication, distribution, etc. | 2010 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 118 p. : |
| Other physical details | ill. |
| 490 1# - SERIES STATEMENT | |
| Series statement | Dissertation ; |
| Volume/sequential designation | no. EV-10-06 |
| 500 ## - GENERAL NOTE | |
| General note | A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Environmental Engineering and Management |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Asian Institute of Technology - Chulabhorn Research Institute - Mahidal University, 2010 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Concerns over adverse effects of pesticide -induced immunotoxic effects are heightened; however , knowledge on this area is relatively still limited . Subsequent to the discovery of non- neuronal cholinergic system in lymphocytes; suggesting that it might be susceptible to pesticides exposure. Pesticides namely, permethrin (PM), deltamethrin (DM), pa raquat (PQ), and paraoxon (PO) were selected to study for their immuno toxic effects. PM and PQ were studied in mice challenged with Plasmodium berghei . The resul ts showed that survival time of mice was significantly reduced and parasitemia percentages of PM- treated groups were slightly higher than control group as a result of prior oral exposure to PM for 14 days and during malaria infection . In contrast, PQ did not increase host susceptibility to Plasmodium infection in PQ -treated mice. The in vitro study showed that all selected pesticides reduced viability of SH -SY5Y, human neuroblastoma and MOLT -3, human leukemic T -lymphocytes cells. The effects of PO were fur ther investigated in SH -SY5Y and MOLT -3 cells. PO were able to induce change s of cholinergic system in both cells in a more or less similar response profile demonstrated by over -expression of AChE, a marker of apoptosis, alterations of M1, M2, and M3 mAChR s mRNA or protein s, and activation of the 2early responsive gene3 c -Fos gene expression. Moreover, the PO -induced activation N -AChE and c -Fos in both neuronal and non- neuronal cells were able to p artially be blocked by atropine indicating that mAChRs activ ation is partially involved in the PO -mediated cellular responses. Taken together, the results suggest that certain neurotoxic pesticides can elicit neurotoxic and immunotoxic effects. The similarity of the response profile in both neuronal and non- neuronal cells suggest that biological functions of such components are, more or less, alike. This present study provides initial and additional information in whic h non- neuronal lymphocytic muscarinic receptors are possible potential targets for pesticides -indu ced immunotoxic effects. In addition the present study also strengthens the belief of using lymphocytes as a surrogate marker for evaluating neurotoxic condition as the consequence of certain pesticides exposure. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Pesticides |
| General subdivision | Physiological effect |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Mice |
| General subdivision | Effect of pesticides on |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jutamaad Satayavivad, |
| Relator term | Chairperson |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Preeda Pakpian, |
| Relator term | Examination Committee |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Apinya Thiantanawat, |
| Relator term | Examination committee |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Sansanee Chaiyaroj, |
| Relator term | Examination committee |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | Chulabhorn Research Institute, |
| Relator term | Scholarship donor |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | Mahidol University, |
| Relator term | Scholarship donor |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | Asian Institute of Technology Fellowship, |
| Relator term | Scholarship donor |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | Royal Thai Government, |
| Relator term | Scholarship donor |
| 810 2# - SERIES ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | Asian Institute of Technology. |
| Title of a work | Dissertation ; |
| Volume/sequential designation | no. EV-10-06 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Materials specified | Full-Text |
| Uniform Resource Identifier | <a href="http://203.159.5.9/ait-thesis/detail.php?q=B00562">http://203.159.5.9/ait-thesis/detail.php?q=B00562</a> |
| 907 ## - LOCAL DATA ELEMENT G, LDG (RLIN) | |
| a | .b12096404 |
| b | mnait |
| c | u |
| 902 ## - LOCAL DATA ELEMENT B, LDB (RLIN) | |
| a | 240403 |
| 998 ## - LOCAL CONTROL INFORMATION (RLIN) | |
| Operator's initials, OID (RLIN) | 0 |
| Cataloger's initials, CIN (RLIN) | 110606 |
| First date, FD (RLIN) | m |
| -- | a |
| -- | u |
| -- | 0 |
| 962 ## - | |
| -- | 000:001:PDF:b1209640:000659:0:0:0:0:0:0 |
| -- | Abstract-AIT Diss. no.EV-10-06 |
| -- | n |
| 945 ## - LOCAL PROCESSING INFORMATION (OCLC) | |
| l | mnait |
| 945 ## - LOCAL PROCESSING INFORMATION (OCLC) | |
| l | mnarc |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | 22-AIT Thesis (Replacement) |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | 40-Archives |
| 909 ## - LOCAL ITEMS USED | |
| Barcode | Barcode : 30050120553788 |
| CREATED | CREATED : 2012-08-16 |
| RECORD Id | RECORD # : i12687443 |
| LPATRON | LPATRON : 1021581 |
| LCHKIN | LCHKIN : 2013-12-07 |
| RENEWALS | # RENEWALS : 0 |
| -- | # OVERDUE : 0 |
| -- | IUSE3 : 0 |
| -- | TOT CHKOUT : 1 |
| -- | TOT RENEW : 0 |
| 909 ## - LOCAL ITEMS USED | |
| Barcode | Barcode : 30050120405799 |
| CREATED | CREATED : 2017-04-20 |
| RECORD Id | RECORD # : i13074738 |
| LPATRON | LPATRON : 0 |
| LCHKIN | LCHKIN : - |
| RENEWALS | # RENEWALS : 0 |
| -- | # OVERDUE : 0 |
| -- | IUSE3 : 0 |
| -- | TOT CHKOUT : 0 |
| -- | TOT RENEW : 0 |
| Withdrawn status | Lost status | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Barcode | Date last seen | Copy number | Price effective from | Koha item type | Cost, normal purchase price |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Available for Loans | Asian Institute of Technology Library | Asian Institute of Technology Library | AIT Publications | 18/08/2026 | AIT Diss. no.EV-10-06 | 30050120553788 | 18/08/2026 | 3 | 18/08/2026 | 22-AIT Thesis (Replacement) | |||||
| Available for Loans | Asian Institute of Technology Library | Asian Institute of Technology Library | Archives | 18/08/2026 | AIT Diss. no.EV-10-06 | 30050120405799 | 18/08/2026 | 18/08/2026 | 40-Archives | 50.00 |