AI SearchThe efficiency of andrographolide in attenuating cadmium-induced hepatotoxicity in rats (Record no. 35530)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 04208nas a2200421 a 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20260818095357.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 080901s2008 th uu|m rtt 0| a1eng d |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | .b12038635 |
| 099 #9 - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | AIT Thesis no.EV-08-45 |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Watanyoo Nakareangrit |
| 245 14 - TITLE STATEMENT | |
| Title | The efficiency of andrographolide in attenuating cadmium-induced hepatotoxicity in rats |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Pathum Thani, Thailand : |
| Name of publisher, distributor, etc. | Asian Institute of Technology, |
| Date of publication, distribution, etc. | 2008 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 39 leaves : |
| Other physical details | ill. + |
| Accompanying material | 1 online resource |
| 490 1# - SERIES STATEMENT | |
| Series statement | Thesis ; |
| Volume/sequential designation | no. EV-08-45 |
| 500 ## - GENERAL NOTE | |
| General note | A thesis sub mitted in partial fulfillment of the requirements for the degree of Master of Science in Environmental Engineering and Management Inter-University Program on Environmental Toxicology, Technology and Management |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (M.Sc.) - Asian Institute of Technology - Chulabhorn Research Institute - Mahidol University, 2008 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The aim of this study was to determine the efficiency of andrographolide (AP) in attenuating cadmium-induced hepatotoxicity in rats in comparison with silymarin (SL), a standard hepatoprotective agent. Rats were treated with CdCl₂ at doses of 0.75, 1.0 mg/kg, intraperitoneal injection (i.p.), for 14 days. For the next 7 days, rats were given oral doses of AP at 6 (AP6), 60 (AP60) mg/kg, and SL at 60 (SL60) mg/kg. The significant decrease of body weight was observed in all Cd-treated rats during the first 14 days and then increased gradually during the drug treatments. Intraperitoneal injection of CdCl₂ had higher levels of cadmium accumulated in liver than kidney. Moreover, Cadmium accumulation also increased in lung, brain and testis of cadmium-treated rats. In Cd0.75-treated group, AP60 significantly decreased Cd accumulation in kidney while this effect was not significant in liver. However, in the Cd1.0-treated group, AP60 and SL60 significantly decreased Cd accumulation in liver. In addition, these drug treatments (AP60 and SL60) could also decrease Cd accumulation in kidney. Administration of AP60 and SL60 may possibly increase cadmium excretion resulting in the reduction of cadmium accumulation in liver and kidney of cadmium-treated rats. All Cd-treated rats showed histopathological changes in liver. The results from liver function test showed that alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities of Cd1.0-treated rats increased significantly. Both AP and SL at 60 mg/kg seemed to decrease these liver enzyme activities induced by cadmium whereas AP at 6 mg/kg did not show this effect. Post-treatment of AP and SL (60 mg/kg) for 7 days was found to attenuate hepatotoxicity induced by CdCl₂. However, AP at the dose 6 mg/kg had no hepatoprotective effect on cadmium-induced hepatic damage. The present results indicated that AP60 is as potent as SL60 for the treatment of hepatotoxicity induced by cadmium. Therefore, AP may have the potential to be used as a hepatoprotective drug against Cd-induced toxicity |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Cadmium |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Hepatotoxicology |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Jutamaad Satayavivad, |
| Relator term | Chairperson |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Preeda Pakpian, |
| Relator term | Examination Committee |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nuchanart Rangkadilok, |
| Relator term | Examination committee |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | Thailand (HM Queen), |
| Relator term | Scholarship donor |
| 810 2# - SERIES ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | Asian Institute of Technology. |
| Title of a work | Thesis ; |
| Volume/sequential designation | no. EV-08-45 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Materials specified | Full-Text |
| Uniform Resource Identifier | <a href="http://203.159.5.9/ait-thesis/detail.php?q=B02433">http://203.159.5.9/ait-thesis/detail.php?q=B02433</a> |
| 907 ## - LOCAL DATA ELEMENT G, LDG (RLIN) | |
| a | .b12038635 |
| b | mnait |
| c | u |
| 902 ## - LOCAL DATA ELEMENT B, LDB (RLIN) | |
| a | 240401 |
| 998 ## - LOCAL CONTROL INFORMATION (RLIN) | |
| Operator's initials, OID (RLIN) | 0 |
| Cataloger's initials, CIN (RLIN) | 080901 |
| First date, FD (RLIN) | m |
| -- | a |
| -- | u |
| -- | 4 |
| 945 ## - LOCAL PROCESSING INFORMATION (OCLC) | |
| l | mnait |
| 945 ## - LOCAL PROCESSING INFORMATION (OCLC) | |
| l | mnait |
| 945 ## - LOCAL PROCESSING INFORMATION (OCLC) | |
| l | mnarc |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | 20-AIT Publication |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | 40-Archives |
| 909 ## - LOCAL ITEMS USED | |
| Barcode | Barcode : 30050120736938 |
| CREATED | CREATED : 2007-04-04 |
| RECORD Id | RECORD # : i12571477 |
| LPATRON | LPATRON : 1015494 |
| LCHKIN | LCHKIN : 2015-04-02 |
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| Barcode | Barcode : 30050120736904 |
| CREATED | CREATED : 2007-04-04 |
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| 909 ## - LOCAL ITEMS USED | |
| Barcode | Barcode : 30050160048855 |
| CREATED | CREATED : 2016-05-31 |
| RECORD Id | RECORD # : i13006058 |
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| Withdrawn status | Lost status | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Cost, normal purchase price | Total checkouts | Full call number | Barcode | Date last seen | Copy number | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Available for Loans | Asian Institute of Technology Library | Asian Institute of Technology Library | AIT Publications | 18/08/2026 | 50.00 | AIT Thesis no.EV-08-45 | 30050120736938 | 18/08/2026 | 1 | 18/08/2026 | 20-AIT Publication | ||||
| Available for Loans | Asian Institute of Technology Library | Asian Institute of Technology Library | AIT Publications | 18/08/2026 | 50.00 | AIT Thesis no.EV-08-45 | 30050120736904 | 18/08/2026 | 2 | 18/08/2026 | 20-AIT Publication | ||||
| Available for Loans | Asian Institute of Technology Library | Asian Institute of Technology Library | Archives | 18/08/2026 | AIT Thesis no.EV-08-45 | 30050160048855 | 18/08/2026 | 18/08/2026 | 40-Archives |