AI SearchExposure to benzene, oxidative DNA damage and genetic polymorphisms among urban and rural schoolchildren (Record no. 42561)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05421nas a2200469 a 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20260818113206.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 080821s2008 th uu|m rtt 0| a1eng d |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | .b12003669 |
| 099 #9 - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | AIT Diss. no.EV-08-2 |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nantaporn Buthbumrung |
| 245 10 - TITLE STATEMENT | |
| Title | Exposure to benzene, oxidative DNA damage and genetic polymorphisms among urban and rural schoolchildren |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Pathum Thani, Thailand : |
| Name of publisher, distributor, etc. | Asian Institute of Technology, |
| Date of publication, distribution, etc. | 2008 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 154 p. : |
| Other physical details | ill. |
| 490 1# - SERIES STATEMENT | |
| Series statement | Dissertation ; |
| Volume/sequential designation | no. EV-08-2 |
| 500 ## - GENERAL NOTE | |
| General note | A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Environmental Engineering and Management Inter-University Program on Environmental Toxicology, Technology and Management |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Asian Institute of Technology - Chulabhorn Research Institute - Mahidol University, 2008 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Traffic related urban air pollution is a major environmental health problem in many large cities. These pollutants contain a variety of carcinogenic compounds including benzene. Children living in urban areas are exposed to benzene and other toxic pollutants simultaneously on a regular basis. Assessment of benzene exposure and oxidative DNA damage in schoolchildren in Bangkok compared with the rural schoolchildren was studied through the use of various biomarkers. Furthermore, the effect of genetic polymorphisms on biomarker levels was investigated. Benzene levels in ambient air at the roadside adjacent to Bangkok schools was 3.95-fold greater than that of rural school areas (Chonburi province) (17.75±2.23 ppb versus 4.49±0.59, P<0.001). Personal exposure to benzene in Bangkok schoolchildren was 3.04-fold higher than that in the rural schoolchildren (8.25±0.78 ppb versus 2.71±0.38, P< 0.001). Blood benzene and urinary benzene levels were significantly increased in the Bangkok schoolchildren. There was a significant increase of afternoon urinary muconic acid (MA) levels in Bangkok schoolchildren compared to rural schoolchildren (0.12±0.01 mg/c, creatinine versus 0.06±0.01; P<0.001). A significantly higher level of 8-hydroxy-2'deoxyguanosine (8-OHdG) in urine was found in Bangkok children than in the rural children (2.13±0.24 mol/mol creatinine versus 1.33±0.20, P<0.05, respectively). An increased level of 8-OHdG in urban schoolchildren compared to the rural group suggests that exposure to ambient air pollution in Bangkok may also contribute to oxidative damage to DNA. There was a significant correlation between individual benzene exposure level and blood benzene (rs=0.193, P<0.05), urinary benzene (rs=0.298, P<0.05), and urinary MA (rs=0.348, P<0.01). In addition, a significant correlation between urinary MA and 8-OHdG in urine (rs=0.07, P<0.05) was also found. CYP2E1 *1/*1, NQO1 *1/*2, GSTA1 *A/*A, GSTM1 *2/*2 and GSTT1 *1/ were prevalent genotypes observed in children in our study. Effects of benzene toxicity varies depend on benzene level in environment, duration of exposure. Gene encoding enzymes that involved in biotransformation of benzene may also modify biomarkers levels. However, among the studied polymorphisms of various xenobiotic metabolizing genes responsible for susceptibility to benzene toxicity, only the GSTM1 genotypes had a significant effect on urinary M A excretion (P<0.05). Schoolchildren who carried the GSTM1 *1/ genotype excreted more urinary MA than those with the GSTM1 *2/*2 genotype. Other genetic polymorphisms (CYP2E1, NQO1, GSTA1, and GSTT1) have no significant effect on blood and urinary benzene, MA and 8-OHdG. Our data indicates that children living in the areas of high traffic density, such as Bangkok are exposed to a higher level of benzene than those living in rural areas. Children who spent more time close to traffic-related sources may be more vulnerable to environmental health threats due to long-exposure term. Exposure to higher level of benzene in urban children may contribute to oxidative DNA damage, suggesting an increased health risk from traffic benzene emission |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Benzene in the body |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Benzene |
| General subdivision | Environmental aspects |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Rural health |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Urban health |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | School children |
| General subdivision | Health and hygiene |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mathuros Ruchirawat, |
| Relator term | Chairperson |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Autrup, Herman, |
| Relator term | Examination committee |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Chongrak Polprasert, |
| Relator term | Examination Committee |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Panida Navasamrit, |
| Relator term | Examination committee |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | Chulabhorn Research Institute, |
| Relator term | Scholarship donor |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | Mahidol University, |
| Relator term | Scholarship donor |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | Asian Institute of Technology Fellowship, |
| Relator term | Scholarship donor |
| 810 2# - SERIES ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | Asian Institute of Technology. |
| Title of a work | Dissertation ; |
| Volume/sequential designation | no. EV-08-2 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Materials specified | Full-Text |
| Uniform Resource Identifier | <a href="http://203.159.5.9/ait-thesis/detail.php?q=B00540">http://203.159.5.9/ait-thesis/detail.php?q=B00540</a> |
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| a | .b12003669 |
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| a | 240401 |
| 998 ## - LOCAL CONTROL INFORMATION (RLIN) | |
| Operator's initials, OID (RLIN) | 0 |
| Cataloger's initials, CIN (RLIN) | 080821 |
| First date, FD (RLIN) | m |
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| 945 ## - LOCAL PROCESSING INFORMATION (OCLC) | |
| l | mnait |
| 945 ## - LOCAL PROCESSING INFORMATION (OCLC) | |
| l | mnarc |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | 22-AIT Thesis (Replacement) |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | 40-Archives |
| 909 ## - LOCAL ITEMS USED | |
| Barcode | Barcode : 30050120725782 |
| CREATED | CREATED : 2012-08-16 |
| RECORD Id | RECORD # : i12686797 |
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| 909 ## - LOCAL ITEMS USED | |
| Barcode | Barcode : 30050160004353 |
| CREATED | CREATED : 2016-09-02 |
| RECORD Id | RECORD # : i1287873x |
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| Withdrawn status | Lost status | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Barcode | Date last seen | Copy number | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Available for Loans | Asian Institute of Technology Library | Asian Institute of Technology Library | AIT Publications | 18/08/2026 | AIT Diss. no.EV-08-2 | 30050120725782 | 18/08/2026 | 3 | 18/08/2026 | 22-AIT Thesis (Replacement) | ||||
| Available for Loans | Asian Institute of Technology Library | Asian Institute of Technology Library | Archives | 18/08/2026 | AIT Diss. no.EV-08-2 | 30050160004353 | 18/08/2026 | 18/08/2026 | 40-Archives |