AI SearchLow level occupational exposure to styrene and benzene : (Record no. 70826)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 04987nas a2200457 a 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20260818153801.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 110606s2010 th uu|m rtt 0| a1eng d |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | .b12096325 |
| 099 #9 - LOCAL FREE-TEXT CALL NUMBER (OCLC) | |
| Classification number | AIT Diss. no.EV-10-05 |
| 100 0# - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sirilak Wongvijitsuk |
| 245 10 - TITLE STATEMENT | |
| Title | Low level occupational exposure to styrene and benzene : |
| Remainder of title | its effects on DNA damage and DNA repair |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Pathum Thani, Thailand : |
| Name of publisher, distributor, etc. | Asian Institute of Technology, |
| Date of publication, distribution, etc. | 2010 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 100 p. : |
| Other physical details | ill. + |
| Accompanying material | 1 online resource |
| 490 1# - SERIES STATEMENT | |
| Series statement | Dissertation ; |
| Volume/sequential designation | no. EV-10-05 |
| 500 ## - GENERAL NOTE | |
| General note | A thesis proposal submitted in partial fulfillment of the requirements for the degree of Doctor of Technical science in Environmental Toxicology, Technology and Management Inter-University Program |
| 502 ## - DISSERTATION NOTE | |
| Dissertation note | Thesis (Ph.D.) - Asian Institute of Technology - Chulabhorn Research Institute - Mahidol University, 2010 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | The present study aimed to evaluate the effects of styrene exposure at levels below the recommended standards of the Threshold Limit Value (TLV-TWA8) of 20 ppm (ACGIH, 2004) in reinforced fiberglass plastics workers. Study subjects comprised 50 exposed workers and 40 control subjects. The exposed workers were stratified by styrene exposure levels, i.e. group I (<10 ppm), group II (10- 20 ppm), and group III (> 20 ppm). The mean styrene exposure levels of exposed workers were significantly higher than those of the control workers. Respiratory particles increased significantly in factory workers (1.05±0.17 mg/m3; p< 0.01) compared to control (0.36±0.93 mg/m3). Factory workers stratified by job activity showed that there was a significant difference of exposure levels among study groups (p<0.01). Respiratory particle level in trimming workers (1.79±0.31mg/m3) was significantly higher than resin laminator workers (0.54±0.05 mg/m3). Biomarkers of exposure to styrene, including blood styrene and the urinary metabolites, mandelic acid (MA) and phenylglyoxylic acid (PGA), were significantly increased with increasing levels of styrene exposure, but were not detected in the control group. DNA damage, such as DNA strand breaks, 8-hydroxydeoxyguanosine (8-OHdG), and DNA repair capacity, were used as biomarkers of early biological effects. DNA strand breaks and 8-OHdG/105 dG levels in peripheral leukocytes of exposed groups were significantly higher compared to the control group (P<0.05). In addition, DNA repair capacity, determined by the cytogenetic challenge assay, was lower in all exposed groups when compared to the control group (P<0.05). The expression of CYP2E1, which is involved in styrene metabolism, in all styrene exposed groups, was higher than that of the control group at a statistically significant level (P<0.05). Levels of expression of the DNA repair genes hOGG1 and XRCC1 were significantly higher in all exposed groups than in the control group (P <0.05). In addition to styrene contamination in ambient air, a trace amount of benzene was also found, but the correlation between benzene exposure and DNA damage or DNA repair capacity was not statistically significant. The results obtained from this study indicate an increase in genotoxic effects and thus health risk from occupational styrene exposure, even at levels below the recommended TLV-TWA8 of 20 ppm. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Benzene in the body |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Styrene |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | DNA damage |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | DNA repair |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Mathuros Ruchirawat, |
| Relator term | Chairperson |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Preeda Pakpian, |
| Relator term | Examination Committee |
| 700 0# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Panida Navasumrit, |
| Relator term | Examination committee |
| 700 1# - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Au, William Wingkam, |
| Relator term | Examination committee |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | The center of excellence on Environmental Health,Toxicology and Mangement of Chemicals (ETM) under Science &Technology Post-Graduate Education, |
| Relator term | Scholarship donor |
| 710 2# - ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | Research Development office (PERDO) of Ministry of Education, Thailand, |
| Relator term | Scholarship donor |
| 810 2# - SERIES ADDED ENTRY--CORPORATE NAME | |
| Corporate name or jurisdiction name as entry element | Asian Institute of Technology. |
| Title of a work | Dissertation ; |
| Volume/sequential designation | no. EV-10-05 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Materials specified | Full-Text |
| Uniform Resource Identifier | <a href="http://203.159.5.9/ait-thesis/detail.php?q=B00561">http://203.159.5.9/ait-thesis/detail.php?q=B00561</a> |
| 907 ## - LOCAL DATA ELEMENT G, LDG (RLIN) | |
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| 998 ## - LOCAL CONTROL INFORMATION (RLIN) | |
| Operator's initials, OID (RLIN) | 0 |
| Cataloger's initials, CIN (RLIN) | 110606 |
| First date, FD (RLIN) | m |
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| 962 ## - | |
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| -- | Abstract-AIT Diss. no.EV-10-05 |
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| 945 ## - LOCAL PROCESSING INFORMATION (OCLC) | |
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| 945 ## - LOCAL PROCESSING INFORMATION (OCLC) | |
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| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | 22-AIT Thesis (Replacement) |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Koha item type | 40-Archives |
| 909 ## - LOCAL ITEMS USED | |
| Barcode | Barcode : 30050120553796 |
| CREATED | CREATED : 2012-08-16 |
| RECORD Id | RECORD # : i12687431 |
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| 909 ## - LOCAL ITEMS USED | |
| Barcode | Barcode : 30050160004080 |
| CREATED | CREATED : 2016-09-02 |
| RECORD Id | RECORD # : i12879198 |
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| Withdrawn status | Lost status | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Barcode | Date last seen | Copy number | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Available for Loans | Asian Institute of Technology Library | Asian Institute of Technology Library | AIT Publications | 18/08/2026 | AIT Diss. no.EV-10-05 | 30050120553796 | 18/08/2026 | 3 | 18/08/2026 | 22-AIT Thesis (Replacement) | ||||
| Available for Loans | Asian Institute of Technology Library | Asian Institute of Technology Library | Archives | 18/08/2026 | AIT Diss. no.EV-10-05 | 30050160004080 | 18/08/2026 | 18/08/2026 | 40-Archives |