AI SearchDevelopment of an SPR-Based biosensor applicable to the rapid and early detection of disease biomarkers
Call Number: AIT Thesis no.ISE-22-09 Material type:
Continuing resourceSeries: Asian Institute of Technology. Thesis ; no. ISE-22-09Publication details: Pathum Thani : Asian Institute of Technology, 2022Description: 60 p. : illSubject(s): Online resources: Dissertation note: Thesis (M. Eng.) - Asian Institute of Technology, 2022 Summary: From centuries, infectious diseases have been one of the main factors influencing human{u2019}s mortality rate, thus disease{u2019}s detection is crucial to keep it low. It has been proved that early detection of diseases can potentially ease the severity and increases precise diagnosis for proper treatment. This research will be focused on stimulating biosensor usage by applying an optical biosensor in detecting glycated albumin which is a mockup of a biomarker. By using an optical biosensor applied with surface plasmon resonance (SPR) in detecting glycated albumin in order to analyze SPR peak shift of gold particles that deposit on ZnO nanorods which have aptamers immobilization on the gold surface. In this research, the biosensor has been used to evaluate glycated albumin at several concentrations and it has been found that the glycated albumin could be rapidly analyzed that the biosensor can detect. In future implications, this research could be potentially further developed to be used with a biomarker that is a real infectious disease to increase the disease{u2019}s detection preciseness and speediness.
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Asian Institute of Technology Library Archives | AIT Thesis no.ISE-22-09 (Browse shelf(Opens below)) | Not for loan | |||||||||||||||
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Asian Institute of Technology Library Archives | AIT Thesis no.ISE-22-09 (Browse shelf(Opens below)) | 1 | Available | 30050121041692 |
Thesis (M. Eng.) - Asian Institute of Technology, 2022
A thesis submitted in partial fulfillment of the requirements for the degree of Master of Engineering in Nanotechnology
From centuries, infectious diseases have been one of the main factors influencing human{u2019}s mortality rate, thus disease{u2019}s detection is crucial to keep it low. It has been proved that early detection of diseases can potentially ease the severity and increases precise diagnosis for proper treatment. This research will be focused on stimulating biosensor usage by applying an optical biosensor in detecting glycated albumin which is a mockup of a biomarker. By using an optical biosensor applied with surface plasmon resonance (SPR) in detecting glycated albumin in order to analyze SPR peak shift of gold particles that deposit on ZnO nanorods which have aptamers immobilization on the gold surface. In this research, the biosensor has been used to evaluate glycated albumin at several concentrations and it has been found that the glycated albumin could be rapidly analyzed that the biosensor can detect. In future implications, this research could be potentially further developed to be used with a biomarker that is a real infectious disease to increase the disease{u2019}s detection preciseness and speediness.
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