03499nas|a2200409 i 4500 20260818085123.0 030418s2002 th uzm rtt 00| a1eng d .b11880788 AIT Thesis no. BP-02-07 Sirikanya Vibhasiri Controlled release of drugs from chitosan membrane and gel Bangkok : Asian Institute of Technology, 2002 82 leaves Thesis ; no. BP-02-07 Thesis (M.Sc.) - Asian Institute of Technology, 2002 A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science, School of Environment, Resources and Development Chitosan matrix system in the form of membrane and semi-solid gel was in vestigated for appli cation in controlled drug deli very system. In this study, two chitosan samples differing in degree of deacetylation (69% and 89%DD) prepared from shrimp chitin were used. The chitosan membranes were prepared by a casting technique using acetic acid as a solvent. The membranes were characterized in the forms of swelling index and permeability behavior of the model drugs (lidocaine hydrochloride and progesterone). The lesser swelling index and more sustained permeation were found with the membrane prepared from 89% DD in compare to membrane prepared from 69% DD chitosan. Drug loaded membranes were prepared and studied for the release pattern. The membranes were th in, transparent and homogenous. The fast release pattern was observed in the initial first hour, whereas the drug release showed more sustained in the later hours depending on the types of chitosan membranes used. More sustained release was obtained with the membrane prepared from higher %DD. In addition, it was observed that release of drug could be controlled by using rate controlled chitosan membrane as permeation barrier screened on the drug loaded membrane. N-acetylchitosan gels were prepared by acetylation of chitosan with acetic anhydride. The semi-solid gels were transparent and elastic. The gel can be exploited as a drug reservoir and as controlled release drug carrier. The rate of drug release was constant within the first hour from lidocaine hydrochloride loaded gel, and up to six hours from progesterone loaded gel. Sustained release of drug was obtained with the use of Nacetylchitosan membrane as rate controlled device. Chitosan Controlled release Drugs Controlled release Stevens, Willem Frans, Chairperson Suwalee Chandrkrachang, Examination Committee Preeda Pakpian, Examination Committee Korbtham Sathirakul, Examination Committee Royal Thai Govenment, Scholarship Donor Asian Institute of Technology. Thesis ; no. BP-02-07 Full-Text http://203.159.5.9/ait-thesis/detail.php?q=B08087 .b11880788 mnait u 240403 0 030418 m a u 0 mnait mnarc 22 40 Barcode : 30050120682900 CREATED : 2013-06-09 RECORD # : i12739911 LPATRON : 0 LCHKIN : - # RENEWALS : 0 # OVERDUE : 0 IUSE3 : 0 TOT CHKOUT : 0 TOT RENEW : 0 Barcode : 30050120350623 CREATED : 2016-10-06 RECORD # : i13030139 LPATRON : 0 LCHKIN : - # RENEWALS : 0 # OVERDUE : 0 IUSE3 : 0 TOT CHKOUT : 0 TOT RENEW : 0 23199 23199 0 0 0 0 MAIN MAIN mnait 2026-08-18 50.00 0 AIT Thesis no. BP-02-07 30050120682900 2026-08-18 08:51:23 3 2026-08-18 22 0 0 0 0 MAIN MAIN mnarc 2026-08-18 0 AIT Thesis no. BP-02-07 30050120350623 2026-08-18 08:51:23 2026-08-18 40