Peerawich Sukcharoenchaikul creator Ricco, Raffaele Chairperson Trau, Dieter Wilhelm Examination committee Bora, Tanujjal Examination committee Royal Thai Government Fellowship Scholarship Donor text th Pathum Thani Asian Institute of Technology 2022 continuing eng 60 p. : ill. From centuries, infectious diseases have been one of the main factors influencing human{u2019}s mortality rate, thus disease{u2019}s detection is crucial to keep it low. It has been proved that early detection of diseases can potentially ease the severity and increases precise diagnosis for proper treatment. This research will be focused on stimulating biosensor usage by applying an optical biosensor in detecting glycated albumin which is a mockup of a biomarker. By using an optical biosensor applied with surface plasmon resonance (SPR) in detecting glycated albumin in order to analyze SPR peak shift of gold particles that deposit on ZnO nanorods which have aptamers immobilization on the gold surface. In this research, the biosensor has been used to evaluate glycated albumin at several concentrations and it has been found that the glycated albumin could be rapidly analyzed that the biosensor can detect. In future implications, this research could be potentially further developed to be used with a biomarker that is a real infectious disease to increase the disease{u2019}s detection preciseness and speediness. A thesis submitted in partial fulfillment of the requirements for the degree of Master of Engineering in Nanotechnology Thesis (M. Eng.) - Asian Institute of Technology, 2022 Surface plasmon resonance Biosensors Asian Institute of Technology. http://203.159.5.9/ait-thesis/detail.php?q=B18183 http://203.159.5.9/ait-thesis/detail.php?q=B18183 230203 20260818090812.0