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| 008 | 020125s2001 th uu|m rtt 0| a1eng d | ||
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| 099 | 9 | _aAIT Thesis no.EV-01-5 | |
| 100 | 0 | _aChate Jaikunya | |
| 245 | 1 | 0 | _aStudy of possible health effects of styrene exposure on reinforced-plastics workers |
| 260 |
_aBangkok : _bAsian Institute of Technology, _c2001 |
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| 300 | _a81 leaves | ||
| 490 | 1 |
_aThesis ; _vno. EV-01-5 |
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| 500 | _aA thesis submitted in partial fulfillment of the requirements for the degree of Master of Science. Inter-University Program on Environmental Toxicology, Technology and Management, School of Environment, Resources and Development | ||
| 502 | _aThesis (M.Eng.) - Asian Institute of Technology, 2001 | ||
| 520 | _aDue to the high exposure of styrene in many occupational settings, to study the amount of styrene exposure in term of both external and internal doses in relate to the potential adverse health effect would be relevant to assessing and preventing workers from exposure to this chemical. The objective of this research is to study the levels of exposure to styrene and its possible health effects in workers in the reinforced-plastic manufacture. Biological monitoring of exposure to styrene in the workplace is an important component of this study. Firstly, the measurement of styrene in workplace was conducted and the means detected level was 18.96 æg/L. This level indicated the low level when compared with the recommended level (TWA). The external dose or exposure level was measured as the level of styrene in the breathing zone of workers, and mean level was 32.74 æg/L. The internal dose levels were determined in the blood and urine of workers and control people. In the blood samples of workers styrene was found at the means levels of 163.41 æg/L, but it was not detected in the control blood sample. The comparison of the styrene levels in the breathing zone and in the blood showed a significant conelation in the workers. The urine was used for the determination of styrene's metabolites, Mandelic acid (MA) and Phenlyglyoxylic acid (PGA). In both workers and the control groups a high variation of MA levels, both in the beginning and the end of workshift was found. The means MA level in the workers at the beginning of the workshift was 1,142 mg/g creatinine, and at the end of the workshift was 2,247 mg/g creatinine. In the control group, the means MA level at the beginning ofworkshift was 795 mg/g creatinine, and at the end of workshift was 1,348 mg/g creatinine. The results of PGA levels also showed a high variation in workers but PGA was not detected in the control group, at the beginning of workshift found 30 mg/g creatinine, and at the end ofworkshift found 43 mg/g creatinine. The results of MA and PGA levels showed no conelation with styrene levels in the breathing zone and in the blood. However, significant correlation was observed with Spearman coefficient between; MA at the beginning and at the end of the workshift (r = 0.51 ), PGA at the beginning and the end of workshift (r = 0. 77), and MA and PGA at the end ofworkshift (r = 0.40). The high variation of urinary metabolites can be explained by individual variation in the metabolic rate in the body, therefore the interpretation of urinary metabolites with the levels of styrene in breathing zone and blood required the collection of urine sample throughout the entire workshift and pathways extended to 24 hours. In addition, the assessment of possible health effects associated with styrene exposure on the several organ functions should be added in the surveillance program for workers in this manufacture. These are lung function test, the measurement of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, and erythrocyte sedimentation rate (ESR) values. | ||
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_aStyrene _xHealth aspects |
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| 700 | 0 |
_aMathuros Ruchirawat, _eChairperson |
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| 700 | 0 |
_aSamorn Muttamara, _eExamination Committee |
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| 700 | 1 |
_aPanida Navasumrit, _eExamination committee |
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| 710 | 2 |
_aKing Scholarship, _eScholarship donor |
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| 810 | 2 |
_aAsian Institute of Technology. _tThesis; _vno. EV-01-5 |
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_3Full-Text _uhttp://203.159.5.9/ait-thesis/detail.php?q=B08196 |
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