000			04006nas|a2200421 i 4500
005			20260817171302.0
008			040430s2003 th u m rtt 00| a1eng d
035			_a.b11924056
099		9	_aAIT Thesis no.EV-03-19
100	0		_aSiravit Charoenying
245	1	0	_aBenefits and risks of y-irradiation for Curcuma longa products
260			_aPathum Thani, Thailand : _bAsian Institute of Technology, _c2003
300			_a66 leaves : _bill.
490	1		_aThesis ; _vno. EV-03-19
502			_aThesis (M.Sc.) - Asian Institute of Technology, 2003
500			_aA thesis submitted in partial fulfillment of the requirements for the degree of Master of Science. Inter-University Program on Environmental Toxicology, Technology and Management.
520			_aIonizing irradiation is an alternative process for microbial decontamination for spices and herbs including Curcuma longa products. Gamma irradiation at the doses of I 0 and 25 kGy is usually practiced for herbs and pharmaceuticals, respectively. However, irradiation technique is suspected to alter the composition of some of the C. longa products. This study attempts to examine the formation of any new compounds after the gammairradiation process and also to optimize the irradiation of C. longa products at lower dose in order -to prevent any possible formation of new compounds which may cause the toxic effects. Five various sources of C. longa products (non-irradiated), including two samples from "one tambon-one product (OTOP)" project, were irradiated with Cobalt-60 gamma ray at the doses of 2.5, 5, I 0 and 25 kGy. Four different batches of commercial irradiated products (capsule) from one company were analyzed. Determination of heavy metals contaminated in C. longa products i.e. cadmium, arsenic, mercury, lead and iron were also performed. The pattern of Thin Layer Chromatography (TLC) with phosphomolybdic spraying showed no considerable changes of TLC patterns between non-irradiated (non-treatment) and irradiated (treatment) samples and without any new band. However, TLC pattern of the four commercial irradiated capsules showed that there was at least one TLC band different from other samples. This may be due to other excipients or diluents added in the capsule during manufacturing process. Irradiation at the dose of I 0 and 25 kGy completely eliminated the microorganisms and the dose of 5 kGy reduced the total viable number of bacteria and fungi down to limited values, whereas 2.5 kGy was less effective. According to these results, it is indicated that gamma-irradiation at the dose range of 5-10 kGy depending on bioberden is sufficient to decontaminate the microorganisms in C. longa products without any changes on the active compounds. High levels of iron (Fe) and cadmium (Cd) were also found in some C. longa products. Further study should be conducted to evaluate the toxicity of crude or extract of irradiated C. longa products.
650		0	_aGamma rays
650		0	_aIrradiation
650		0	_aTurmeric
700	0		_aJutamaad Satayavivad, _eChairperson
700	0		_aPreeda Pakpian, _eExamination Committee
700	0		_aPaiboon Vattanaviboon, _eExamination committee
700	0		_aNuchanart Rangkadilok, _eExamination committee
710	2		_aHer Majesty the Queen, _eScholarship donor
810	2		_aAsian Institute of Technology. _tThesis ; _vno. EV-03-19
856			_3Full-Text _uhttp://203.159.5.9/ait-thesis/detail.php?q=B08242
907			_a.b11924056 _bmnait _cu
902			_a240417
998			_b0 _c040430 _dm _ea _fu _g0
945			_lmnait
945			_lmnarc
942			_c22
942			_c40
909			_aBarcode : 30050120706642 _bCREATED : 2014-04-02 _cRECORD # : i1275593x _dLPATRON : 0 _eLCHKIN : - _f# RENEWALS : 0 _g# OVERDUE : 0 _hIUSE3 : 0 _iTOT CHKOUT : 0 _jTOT RENEW : 0
909			_aBarcode : 30050160051214 _bCREATED : 2016-05-25 _cRECORD # : i12990450 _dLPATRON : 0 _eLCHKIN : - _f# RENEWALS : 0 _g# OVERDUE : 0 _hIUSE3 : 0 _iTOT CHKOUT : 0 _jTOT RENEW : 0
999			_c11619 _d11619