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008			100204s2009 th uu|m rtt 0| a1eng d
035			_a.b12072643
099		9	_aAIT Diss. no.EV-09-05
100	0		_aSunisa Sangjun
245	1	0	_aChemopreventive properties of stilbene derivatives in human breast and prostate cancer cell lines
260			_aPathum Thani, Thailand : _bAsian Institute of Technology, _c2009
300			_a1 online resource (97 p.) : _bill.
490	1		_aDissertation ; _vno. EV-09-05
500			_aA dissertation submitted in partial fulfillment of the requirements for thedegree of Doctor of Technical Science in Environmental Engineering and ManagementInter-University Program on Environmental Toxicology, Technology and Management
502			_aThesis (Ph.D.) - Asian Institute of Technology - Chulabhorn Research Institute - Mahidol University, 2009
520			_aThirteen cis-stilbene derivatives (CRI-1 - CRI-13) related to VIOXX®were synthesized and studied for their chemopreventive properties in human breast cancer and prostate cancer cell lines. Based on the different substituents in the stilbene molecule, we established a structure activity relationship (SAR) for cytotoxicity, anti-estrogenicity, cell cycle analysis and apoptosis. The results show that some of these stilbenes have a pronounced effect on these chemopreventive properties. In MCF -7 breast cancer cells, CRI-5, 7, 10, and CRI-12 caused an arrest of the G2/M phase and a reduction of G 1/S phase at various dose levels. CRI -9 only arrest the G 1/S phase in a dose-dependent manner. In addition, some CRr congeners, CRI-6 and 9, have a moderate anti-estrogenic effect. In the LNCaP, prostate cancer cells CRI-5, 7, and 12 arrest the cell cycle in G2/M phase and induced apoptosis. A first SAR for these cis-stilbene derivatives was identified. The presence and position of methoxy and thiomethoxy groups are essential for the tested chemopreventive properties and substitution on the para position of these substituents on the left aromatic ring is a prerequisite. The study shows that some of these synthetic cis-stilbene derivatives have the potential to be chemopreventive agents, as these can effectively interfere with cellular processes those are important for anti-cancer treatment. As these experiments have all been done in tumor cell lines further studies are necessary to identify if these anti-tumor properties can also be found in in vivo situations
650		0	_aStilbene
650		0	_aCancer cells
650		0	_aCancer _xChemoprevention
700	0		_aSomsak Ruchirawat, _eChairperson
700	1		_aVan Den Berg, Martin, _eCo-Chairperson
700	0		_aChongrak Polprasert, _eExamination Committee
700	0		_aPreeda Pakpian, _eExamination Committee
710	2		_aChulabhorn Research Institute, _eScholarship donor
710	2		_aMahidol University, _eScholarship donor
710	2		_aAsian Institute of Technology Fellowship, _eScholarship donor
710	2		_aInstitute for Risk Assessment Sciences (IRAS), Utrecht University, The Netherlands, _eScholarship Donor
810	2		_aAsian Institute of Technology. _tDissertation ; _vno. EV-09-05
856			_3Full-Text _uhttp://203.159.5.9/ait-thesis/detail.php?q=B00552
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