000			03499nas|a2200409 i 4500
005			20260818085123.0
008			030418s2002 th uzm rtt 00| a1eng d
035			_a.b11880788
099		9	_aAIT Thesis no. BP-02-07
100	0		_aSirikanya Vibhasiri
245	1	0	_aControlled release of drugs from chitosan membrane and gel
260			_aBangkok : _bAsian Institute of Technology, _c2002
300			_a82 leaves
490	1		_aThesis ; _vno. BP-02-07
502			_aThesis (M.Sc.) - Asian Institute of Technology, 2002
500			_aA thesis submitted in partial fulfillment of the requirements for the degree of Master of Science, School of Environment, Resources and Development
520			_aChitosan matrix system in the form of membrane and semi-solid gel was in vestigated for appli cation in controlled drug deli very system. In this study, two chitosan samples differing in degree of deacetylation (69% and 89%DD) prepared from shrimp chitin were used. The chitosan membranes were prepared by a casting technique using acetic acid as a solvent. The membranes were characterized in the forms of swelling index and permeability behavior of the model drugs (lidocaine hydrochloride and progesterone). The lesser swelling index and more sustained permeation were found with the membrane prepared from 89% DD in compare to membrane prepared from 69% DD chitosan. Drug loaded membranes were prepared and studied for the release pattern. The membranes were th in, transparent and homogenous. The fast release pattern was observed in the initial first hour, whereas the drug release showed more sustained in the later hours depending on the types of chitosan membranes used. More sustained release was obtained with the membrane prepared from higher %DD. In addition, it was observed that release of drug could be controlled by using rate controlled chitosan membrane as permeation barrier screened on the drug loaded membrane. N-acetylchitosan gels were prepared by acetylation of chitosan with acetic anhydride. The semi-solid gels were transparent and elastic. The gel can be exploited as a drug reservoir and as controlled release drug carrier. The rate of drug release was constant within the first hour from lidocaine hydrochloride loaded gel, and up to six hours from progesterone loaded gel. Sustained release of drug was obtained with the use of Nacetylchitosan membrane as rate controlled device.
650		0	_aChitosan _xControlled release
650		0	_aDrugs _xControlled release
700	1		_aStevens, Willem Frans, _eChairperson
700	0		_aSuwalee Chandrkrachang, _eExamination Committee
700	0		_aPreeda Pakpian, _eExamination Committee
700	0		_aKorbtham Sathirakul, _eExamination Committee
710	2		_aRoyal Thai Govenment, _eScholarship Donor
810	2		_aAsian Institute of Technology. _tThesis ; _vno. BP-02-07
856			_3Full-Text _uhttp://203.159.5.9/ait-thesis/detail.php?q=B08087
907			_a.b11880788 _bmnait _cu
902			_a240403
998			_b0 _c030418 _dm _ea _fu _g0
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909			_aBarcode : 30050120682900 _bCREATED : 2013-06-09 _cRECORD # : i12739911 _dLPATRON : 0 _eLCHKIN : - _f# RENEWALS : 0 _g# OVERDUE : 0 _hIUSE3 : 0 _iTOT CHKOUT : 0 _jTOT RENEW : 0
909			_aBarcode : 30050120350623 _bCREATED : 2016-10-06 _cRECORD # : i13030139 _dLPATRON : 0 _eLCHKIN : - _f# RENEWALS : 0 _g# OVERDUE : 0 _hIUSE3 : 0 _iTOT CHKOUT : 0 _jTOT RENEW : 0
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